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Sunday, February 18, 2018

Darwin, drowning and reset



This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

By Charles-Edouard!

Darwin's Anniversary: if only he had known of mutations...

Afficionados will follow PZ Myers on YouTube, and this excellent series by the Museum.

Darwin is the common ancester: your mutant viruses are descendants of your 'historical' virus. We will revive it: it's Jurassic Park directed by Leibowitch!


What is drowning


It is described by Leibowitch: Antiviral treatment was momentarily interrupted in patients 5, 6, 8, 11, 12, and 13 for 6 months or more in an attempt to “drown out” the recentlymutated HIV in a wave of returningWTHIV (49, 50). Therefore, patients 5, 8, and 13 could resume 7 day per week attack combinations comprising drugs previously deemed ineffective against the mutant virus at the time of escape. [The fact that the combinations, now successful on a 7 (patient 8), 4 (patient 5), or 3 (patient 13) day per week regimen, comprised one or more antiviral components genotypically “unfit” against the preinterruption mutant virus supports the notion that the mutant species had functionally been “washed out.”].

In an environment that is no longer adverse, the wild type virus, takes over. Finally ... Your virus that is the least mutated, ie your initial virus. These 'children', mutants, have a lower fitness, they will disappear. Your initial mutations (those of your initial genotype) will not disappear. It is the 'historical' virus which takes place, at the price of a therapeutic holiday of at least 6 months (it is not done in 5 minutes ...).

Drowning: RESET and controversy


Leibowitch, has demonstrated, on more than fifteen patients, that one can thus delete past errors and ridicules those who preach over treatment. Professor Katlama had tried it, in a fashion most favorable for to failure (2 months of drowning only), burying it with her usurped weight, killing any attempt of development. The toolbox thus amputated, any serious research of the optimal posology, the mission of phase 4, incumbent on the clinic, is embarrassed: do not be surprised then by the monumental error which puts millions of patients in the physical and psychic suffering, and others in the shortage or lack of treatment.

Drowning and reservoir


The dominant concept is that the reservoir is an accumulation pile: the new mutants are inscribed in it, in an irreducible way, and stand out ineluctably: this makes the reservoir an inertial mass, immutable when it comes to destroying it, and accumulating all the ugly boys, on top of that... It evolves but only in a way that is unfavorable to us. If, on the contrary, we give credit to drowning, then we benefit from this so much hated reservoir (because it has archived the historical virus, the least unfavorable), and its purge (qualitative, not quantitative) is the proof that it can be manipulated qualitatively (the quantitative manipulation, the shock and kill, is, for the time being, a failure)

Drowning: an exploration tool


Drowning is an indispensable part of the exploration toolbox. You have to understand it, accept it, assume it. This is all the easier if you entered treatment early. Treatment has permafrosted your situation. You will come back soon enough to the previous situation, and if this situation was favorable (eg high initial CD4) then you have, on paper, the necessary time. If, conversely, you were treated 'late' ...

Mono-DTG: not the bomb we hoped for ... too bad!


I made several approaches to using Mono-DTG for my reductionist purposes. The dose reduction, the short cycle, the ultra-short cycle (with first beacons towards 1/7 and 1/15). Dose reduction (1/2 of a pill then 1/4 of a pill, in 7/7 worked very well, as well as 4/7 at 50 mg.) My 2 attempts at 1/7 (DTG 100 mg + 3TC 300 mg and DTG 150 mg, alone, in 1/7) failed. The failure to DTG 150 mg, alone, in 1/7 is without appeal, it is frank, massive.

It may be a little different, I do not know ... Still, for me, it's not the 'bomb' needed to return beyond 1/7. In retrospect, I might have been better off staying on a proven strategy (Leibo's 4-T) that I pushed further: 1/15 and 1/21!

The depressive effects of DTG are, for me, a reality. Dilemma. I try a ressupression with massive doses. If it works, I'll take up my pilgrim's staff again, with the 4-T, otherwise, I'll drown everything for a good year, which on paper should be possible.

I have empathy for those who have tried and will not necessarily have succeeded. Those who have not tried anything (or with pointless strategies), ex. Katlama, did not help us ...

In the news


- BMS, Videx: end of sale of VIDEX and ZERIT end of March 2018. The ANSM announces a generic (Laboratory Arrows), but ... Users should be prepared!

- In 50% of the cases, mini-VL-uptakes are laboratory errors

French touch


Dr. Alain Lafeuillade has published a book: A doctor should never say that .... He had baptized HypoDolu. For me, MicroDolu (1/4 of a pill 7/7) works, but not Hypodolu ... Well... He is a fighter, so it must be interesting to read. 10 euros

Consider also Leibowitch's book: To-finish-with-AIDS: where he esplains drowning ...

Have a good Week, good fuck and do not abuse of meds/drugs

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Sunday, February 11, 2018

Mono-DTG: an all new VICTORY



This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

Mono-DTG: an all new VICTORY

By Charles-Edouard!


Lanzafame: Total success in Mono-DTG maintenance


Dolutegravir tivicay monotherapy lanzafame cure hiv cabotegravir
Lattuada, Lanzafame et al. publish 25 maintenance patients under Mono-DTG: Dolutegravir monotherapy in HIV-1-suppressed patients: A feasible regimen in real life

ZéRo failures!

Like us, Dr. Lanzafame identifies Achille's Heel and good adherence as a criterion. The theoretical failure rate, based on the 125+ patients of BMM + P, is 1-2%. They do as in our Mono-DTG practical guide and have no failure:


This is the first post-BMM + P and post-DOMONO report: those who predicted the total failure of Mono-DTG are busted! (and nobody tells you about it...)

More than 200 patients in success under mono-DTG!


3 years after the approval of Tivicay®, we already have more than 200 patients in success (100+ in BMM + P, 50 in DOMONO, 25 in maintenance and 25 in first line at Lanzafame). The DOMONO authors offered the 61 patients, in success under Mono-DTG, to return back to Tri. The sneers chuckled! Except that ... 59 simply refused! Faced with a supposed, possible and undifferentiated risk, 97% of patients refuse to leave Mono-DTG: they do not believe it!

Here is an interesting pool for the partial, even total, remission a little like the Viscontis!

Mono-DTG and short cycle: 4/7


Subject to the selection criteria (genotype on INI), mono-DTG is an absolutely acceptable first-line treatment, and therefore a good candidate for the ICCARRIAN descent. We could redo the very first trial: 7 days ON followed by 7 days OFF.

In our new survey (top left): all voters think that under effective Mono-DTG, we could cycle. 3 arguments are in favor of a doses reduction: pharmacokinetics, Cabotegravir at ... 30 mg, pharmacodynamics.

Pharmacokinetics are Permissive: use it!


A study, by Elliot et al., funded by ViiV (hi, hi, hi ...) shows that DTG has a more interesting profile, more permissive, than EVG. It shows, above all, that DTG remains above its IC90 (64 ng / mL) more than 72 hours after interruption. They explain that the pharmacokinetic persistence makes DTG a good candidate for FOTO or BREATHER sequels.

pharmacokinetics monotherapy Dolutegravir tivicay elvitegravir genvoya skip dose


Cabotegravir 30 mg or Tivicay ® 25 mg (1/2 pill)?


Lanzafame does with what is available: Tivicay® 50 mg. Soon, Cabotegravir 30 mg will be available. Will he try, tomorrow, CTG 30 mg in maintenance? Why would he not?

But, here ... We know that CTG and DTG is six of one and half a dozen of the other. CTG is not yet available while it is already technically possible to use DTG 25 mg (1/2 pill).

Eclipse and delayed effect


Under effective and truly effective treatment, the Eclipse exists for everyone: it is a fundamental and foundational Anti-RetroViral feature, not an anecdotal performance. The effect of pharmacodynamic remanence under Mono-DTG (and Mono-Bictegravir, for that matter) is known since the ING111521 trial.



Dolutegravir, Absolutegravir, remission and medical malpractice


At the turn of the century, remission attempts, with inefficient molecules, had failed. Dolutegravir is a game changern: for many patients / viruses, it is an Absolutegravir. In monotherapy (perhaps not in tri ...) it opens an opportunity for total or partial remission.

The patient who starts RAL or EVG as first-line or in maintenance (if there are other options) makes a serious and potentially adverse decision to her legitimate hope for remission.

Likewise, the patient, under effective Mono-DTG, who would close her eyes on ICCARRE, deprives herself of a potential remission, at least partial.

Well ... we can say THANK YOU! to Lanzafame and the team of Verona!

In the news


- The variety marchants did not appreciate the prospect of a weekly drug, but then there, not at all and let it know!

- The statineur cardiologists did not appreciate the rebroadcast of ""Cholesterol: the Big Bluff". Their argument (link): alarmed (see here), many patients have stopped medication and a study will prove excess mortality: Professor Moore (Bordeaux) announced such a study more than a year ago, and since then it's total silence! There is a world between announcing a study and prejudging its result! A truebluff! Statins: The Great Pshiiiit?

- Irene Frachon explains the basics of corruption . Uplifting!

- Prescrire publie sa liste its list of authorized but dangerous drugs

- Hepatitis B: vaccination for subjects at risk: to be considered; for all infants: an ineptitude. Marc Girard dissects how we got there. Read here too. Brigitte Autran sheds another light.

Have a good Week, good fuck and do not abuse of meds/drugs

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Saturday, February 3, 2018

098



This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.




EACS and Nuremberg backpedal #1

By Charles-Edouard!

I have retained in this detailed testimony:

The first of the overmedications is the abusive extension of indication: crime encouraged by the medical-pharmaceutical underworld. Crime as well. This is the genius of proposal 1/7. Besides, I find it difficult to understand why a patient, thus abused and then disillusioned, is not told that she always has the possibility of interrupting the treatment: at high nadir, there is no demonstrated over-risk (see Salto or Lotti, and even SMART, if you read them critically)

Nuremberg and the crime against dignity


At the beginning of the XXth century, 'medical' interventions for the benefit of society (for the benefit of others) were born, including eugenics. Before the war, no scientist or doctor was convinced that castrating 'idiots' would improve mankind. Some American states voted eugenic laws, the Scandinavians went full steam ahead, and the Nazi regime pushed it to the extreme. The war ends, we discover the medical horrors in the name of progress. A crime was introduced that was superior to all others: that of depriving a human being of his or her humanity: this was the Nuremberg Code. See the video of Pr. P-H Guyon. It is applied to trials: it applies, in fact, to daily practice.

Altruistic, non-altruistic (selfish) profit and crime


Performing a (medical) intervention on a person, for the benefit of others, is altruistic (the root 'others' is found there). Since Nuremberg, it is forbidden. A part of the medical profession regrets eugenics, or indulges in this inclination. As a proof, the compulsory vaccination of infants: they sell you that vaccinating your little one, at the risk of complications (rare but serious), protects grandma and grandpa, in a retirement home. There is no word to express the opposite of altruistic. The term 'egoist' is used, which is unfortunately connoted. Thus the famous work of R. Dawkins, the selfish gene must be understood: the gene is not altruistic.

According to the 'Nuremberg code', altruistic intervention is a crime. Non-altruistic intervention, for the benefit of the person, is allowed. The same goes for the intervention that is for the benefit ('selfish') of the person as a principal, while being, as an accessory, for the benefit of others.

The trick is therefore to mask the benefit to others with a dose of personal benefit.

The shameless use of statins is a crime but no one has claimed a benefit to others...
Vaccinating infants against hepatitis B, which is essentially sexually transmitted, does not benefit them: it is both a crime against them and against their dignity.

In the framework of TasP (Treatment as Prevention), if one advocates (or practices) putting people on treatment, even at high CD4 levels, there is a benefit for others (non-infectiousness), but the benefit for the person, strictly speaking, is non-existent, in our tropics. The excess risk only exists in a specific geographical context: the South (to make a long story short)

In the North, and except in the case where the patient wishes to become non-infectious(quite legitimate), pushing or advocating treatment at a high CD4 level has no health benefit. This is an abusive procedure, which makes the patient a victim of altruistic hysteria.

EACS recommendation: the great retropalation


The EACS, ad hoc vehicle of over-medication(not self-funded...), publishes 'recommendations' which are to Science what advertorial is to serious journalism: advertising in disguise. By pushing the envelope too far, one discredits oneself and the backtracking was anticipated in my post: Morlat is deceiving you.

The last edition is a backtracking that no one will have told you about: and for good reason: the abusive (aka altruistic) treatment is at the heart of the alliance between the medical-pharmaceutical mob and commentators. To see it, just compare the latest version (100 pages...) to the previous versions. Plus, it is well hidden.

It's well hidden, so we don't do it in one tweet... In a future post, we'll see how EACS deprives you of the insight needed for consent(there, no change... ), and, more importantly, how the backpedaling and its concealment exposes the 'altruistic' obsession, which, this post is about, is a crime...

In the news


Reservoir content can be altered: Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs

An article from Le Monde: The Church recognizes a new miracle at Lourdes: and not to ask questions. What a miracle! Well... 50% of people are more credulous than the average, and some take advantage of it. They are swindlers...

The French genius


Here is an interview by Michel Collaro Cult: treating yourself with wine. Indication, dosage and reimbursement, everything is covered... Not a hoax: the book really exists!

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good weekend, good stuffing and not too many meds ... Huh?