Search This Blog

Saturday, June 17, 2017

Eclipse's Equation



Our readership explodes: we have new projects, we need help! we are looking for translators and also voices for podcasts. Someone to animate via social networks would also be of great help! You like this blog, so, please help!


This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

The Eclipse and its beloved Equation

By Charles Edouard!

We publish, at the bottom of this post, 3 comments/contributions by Dr. Leibowitch. Read them!

Your testimonials are useful: here is one exemple ...
The START trial offered Freedom, to anyone who so wishes, to treat, without waiting. But to treat blindly, without discernment, is a collective hysteria. The allevaition is also made without any ratio condition (see Dr de Truchis). For Mono-Tivicay® see Dr Lafeuillade, in Toulon.

The Eclipse is not the one you think!


People have trouble understanding the Virus' Eclipse, that is a fact. Here is a rather classic view. (I have, in preparation, another version that will blow your mind ...)

According to a conjecture by Pr. Siliciano (2003), the reservoir is the cause for the rebound and this reservoir decreases only so slowly that there is hope to see the end of it. This is a vision of the twentieth century, already so ancient ...

In a recent publication (Hill et al., 2014), he has designed a model, in his Laboratory, that good common sense commands: rebound is a stochastic phenomenon (random in time), greater (long)as the reservoir is smaller. It is a classic Poisson phenomenon, nothing new under the sun... Slim Fourati made early interesting findings, as early as 2012. Bruner and the Silicianos show that defective proviruses accumulate rapidly within the first few weeks of infection to make up over 93% of all proviruses, regardless of how early ART is initiated. 75-95% of the reservoir is junk. (and so are the rambling rhetorics by Pr. Rouzioux-des-Critères ... Let's not be distracted ...). See also here.

We would like to be able to predict the Eclipse, have reasonable expectations and ditch the Great Priests of Immediate Resurgence.

We know two components: a pharmacokinetic wash-out + an exponential kinetic of reseeding. The deeper the suppression, the further below this kinetic will restart from.

In a short cycle, the ON period deepens the re-suppression. Does it allow you to go the ultimate bottom? We do not give a damn ... By the time you cogitate and you are already at the Week-end break (or 4/7, 2/7 ...).

CD4 susceptibility


The CD4 is more or less receptive, depending on the relative position of the CCR5 co-receptor (or even XR4 in the case of bi-tropism). Cells without CD4 receptors (eg, neurons) are unaffected. If the CCR5 is blocked by delta 32 (homozygous or heterozygous), the susceptibility decreases, or even becomes zero, as has been induced in the Berlin patient. It also decreases after activation has cooled down: therefore we wait a little before entering the Short Cycle.

The natural immune response (CD8)


Elite controllers are here as a proof. Found rarely, the HLA-B * 27 or HLA-B * 57 alleles increase the generation of keys, thus the arms race runs less to the virus' advantage. The immune response, say, to the level of an induced CD8 efficiency (I simplify), exists. Got it.

The size of the reservoir


It is a catch-all drawer, poorly quantified, but, obviously, the rebound comes from it, and, until further notice, we admit its existence. It is quantified so badly that any attempt to use it as a 'criterion' is a first-order stupidity (see comment # 2 by Leibowitch)

The quality, the viability of the reservoir

75 to 95% of the code that inserted itself in your genome (you're a GMO!) is junk, shit, you name it... (as shitty as the rambling rhetorics by...I do not have to repeat myself, we have understood). So it will not serve as a bootstrap. We know how to play on this percentage ... If you treat during the acute phase, the percentage of competent DNA is low ... It does not help us too much: we can not redo the patient history.
It evolves according to the molecules. Wainberg provides a convincing example. So, in order to prepare for a remission, albeit partial, some molecules are better than others. This is taboo ! We'll get back to it!

A basic equation


The time-to-Rebound is the inverse of susceptibility, of the reservoir (quantitative) and in proportion to the natural response and the proportion of Junk.

So we have :

 
Eclipse = wash-out +
 
(proportion of Junk x immune response)
_________________________________
( Proviral DNA x Susceptibility)
 
+ etc.
 

There you go! Not everyone is in the same boat, and it changes over time; The case-by-case recommendation, in the Morlat report (aka French Guidelines) is going to be very difficult to assess by the doctor. She does not have the tools nor the charts to interpret them ... (see comment # 3 by Leibowitch)

We will soon see how to turn this to our advantage and put remission back on the table.

Good Weekend, good fuck, and build your stock: France is heading to social collapse!

Comments (Dr. Jacques Leibowitch)


Comment # 1 by Jacques Leibowitch 12 June 2017

Comment # 2Jacques Leibowitch 12 June 2017


Comment # 3 Jacques Leibowitch 12 June 2017




Our readership explodes: we have new projects, we need help! we are looking for translators and also voices for podcasts. Someone to animate via social networks would also be of great help! You like this blog, so, please help!


This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

No comments:

Post a Comment