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Friday, May 12, 2017

First-line Tivicay Monotherapy

First-line Tivicay Monotherapy
This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

First-line with Mono-DTG

By Charles Edouard!

Here is a topical question:

For medical advice, see Pr Katlama or Dr. Lanzafame. What do the tests say? In monotherapy, in ING 111521, 90% of patients passed the <400 mark in just 10 days! Lanzafame initiates the Tivicay ® monotherapy, from the first prescription. As first-line, DTG + 3TC Bitherapy worked well. The proposals DTG + 3TC or Tivicay ® + Truvada ® are not coformulated: they allow monotherapy: just leave the other one in the closet. Dr. Lafeuillade recounts a personal experiment ...

Will the Wainberg hypothesis be validated by Lanzafame?


On a 'wild' (non-mutated) virus, the first mutation to appear is R263K. But it prevents the virus from regaining strength (loss of fitness), and, the reservoir should 'normally' decrease: it falls into a Darwinian black hole .... Adios asshole!

Conversely, if the virus has step-stone mutations or substitutions (I simplify), it can acquire resistance mutations; The benefit of R263K is lost, and that of mono-Tivicay® as well ...

If the Wainberg concept is correct, then, we should see at the clinic:
- a rate of success not too bad, not too good, on already mutated viruses (eg failure to RAL or EVG), and this is what we observe (Viking trial)
- a success rate, in maintenance monotherapy, which depends on the presence of the footsteps: this is what is observed in the BMM + P cohort: it is the Achille's heel.
- an excellent success rate, in first-line on wild type virus: this is what we observe (ING test 111521 + Lanzafame report)

Lanzafame cure remission monotherapy dolutegravir HIV tivicay iccarre first line attack
If the Wainberg / Mesplede theory (the R263K pathway is beneficial) is accurate, the success of DTG monotherapy should not depend on any parameter other than wild-type (or not) nature.

Tivicay® Monotherapy with Naïve Patients: Yessss!


Hence the importance of the latest publication by Dr. M. Lanzafame, who further increased his group of patients using Tivicay® monotherapy as their first therapy (wild virus and a VL <100.000).

Lanzafame cure remission monotherapy dolutegravir success undetectable low CD4

Lanzafame saves the medical honor ... and the world!


He has redone ING 111521: it is a prudent scientific approach, to confirm the results of a commercial trial... This is in line with the result of ING 111521, unexpected at first, then put under the rug or even occulted later.

He chooses his patients, with restrictive conditions on the virus, the 'wildest' possible. And none on CD4: one patient had CD4 = 1, another CD4 = 2!

Lanzafame unveils a new strategy. His patients (why not you?) will therefore benefit from an effective monotherapy, as first line, which opens the door to an alleviation like ICCARRE 4/7. His group will be able to move closer to remission ('cure').

He invites us to reconsider the results of BMM + P (Barcelona, ​​Montreal, Munich) + Paris, where, with selected patients, we have excellent results, contrary to the DOMONO protocol, where patients are not or poorly chosen, and where the result is mediocre.

Obviously, no one told you about this !! If the ignorants and traitors tell you that mono-Tivicay® does not exist, well, now you know that it does... The subject is relaunched from the ethical, clinical, public health angle: we will discuss this soon ...

This blog is not a medical advice: For this strategy, get in touch with Dr Katlama, Lafeuillade or Lanzafame (see list). What about others? Well... They are lagging behind, so you ignore the ignorant, and you go to one of these 3 doctors. Move your ass! And report here!



In this election weekend many will have to swallow a bitter snake...
Not me! This weekend is my first without meds: it is the first of my return to 1/14! And it is real cool!


Comments


Nanar May 21, 2017


Charles-Edouard! May 21, 2017



This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

2 comments:

  1. Hello,

    I take a Isentress + Intelence bitherapy that works well since I am undetectable, but I can not stand that well. I ask myself the question of going to Iccarre or a monotherapy. I will not see my doctor before the end of June to know his opinion so in the meantime you may be able to sehd some light?

    I do not know if a Isentress or Intelence monotherapy would be possible? Does ICCARRE also applies to monotherapies?

    Is it recommanded to consult in Garches to be followed in an Iccarre protocol?

    Thank you in advance

    ReplyDelete
  2. You have ample reasons to take matters into your own hands. For a medical second opinion, you must see a doctor; this blog is not a
    medical advice. It is also necessary to know where to find a real expert who can advise you, supported by a real mastery of the subject. Here we expose published works.

    You are currently taking ETR + RAL: this is the ETRAL proposal, dear to the ANRS and dear (expensive) to the heatlh system. Here we follow the 'strategies'.
    However, the ETRAL proposal does not deserve the name of strategy: it is a pseudo-relief (at 1600 mg / d.!) And especially a cul-de-sac.

    To get out of it, not so simple ...

    You consider a move towards monotherapy. Concerning a possible monotherapy of RAL or ETR, I found nothing in the
    literature and I doubt we can find anything encouraging.

    Tivicay's monotherapy would be attractive, but Prof. Katlama warned users (present or past) of RAL (and / or EVG,
    matter); The majority of failures in Mono-Tivicay maintenance, in BMM + P, had this Achilles heel.

    https://once-weekly-hiv-therapies.blogspot.fr/2016/06/its-achilles-stupid.html

    The ICCARRIAN reduction is also attractive; There, it is true, the best specialists in the world are in Garches (nearly 200 patients published on the counter); It would be a shame not to take advice.
    Especially if you only have to go there once. Garches is dedicated to helping local doctors. Once the strategy (in the true sense of the term) defined in this medical service of world-wide reputation, the follow-up can be done by a near-by doctor, of your choice.

    https://once-weekly-hiv-therapies.blogspot.fr/p/experienced-doctors.html

    ReplyDelete

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